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Sartaxal

Sartaxal belongs to a family of medications known as angiotensin II receptor blockers. These medications are used in adults and children over the age of six to lower mild-to-moderate hypertension (high blood pressure).

Other names for this medication:
Aratan, Eklips, Enromic, Gitox, Lacine, Lopernal, Lorista, Losacar, Losacor, Losadel, Losartic, Losatan, Lostan, Lotan, Lozatan, Lozitan, Lyosan, Ranlozar, Sanipresin, Sarvastan, Sarve, Sedeten, Sortiva, Tanlozid, Xartan

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Also known as: Losartan

Description

Sartaxal (losartan potassium) is an angiotensin II receptor blocker acting on the AT1 receptor subtype. Losartan potassium, a non-peptide molecule, is chemically described as 2-butyl-4-chloro-1-[p-(o-1Htetrazol- 5-ylphenyl)benzyl]imidazole-5-methanol monopotassium salt.

Sartaxal is a white to off-white free-flowing crystalline powder with a molecular weight of 461.01. It is freely soluble in water, soluble in alcohols, and slightly soluble in common organic solvents, such as acetonitrile and methyl ethyl ketone. Oxidation of the 5-hydroxymethyl group on the imidazole ring results in the active metabolite of losartan.

Sartaxal is available as tablets for oral administration containing either 25 mg, 50 mg or 100 mg of losartan potassium and the following inactive ingredients: microcrystalline cellulose, lactose hydrous, pregelatinized starch, magnesium stearate, hydroxypropyl cellulose, hypromellose, and titanium dioxide.

Sartaxal 25 mg, 50 mg and 100 mg tablets contain potassium in the following amounts: 2.12 mg (0.054 mEq), 4.24 mg (0.108 mEq) and 8.48 mg (0.216 mEq), respectively. Sartaxal 25 mg, Sartaxal 50 mg, and Sartaxal 100 mg may also contain carnauba wax.

Dosage

Usual Adult Dose for Diabetic Nephropathy:

Initial dose: 50 mg orally once a day Maximum dose: 100 mg orally once a day Comments: -If hypertensive patients with left ventricular hypertrophy or type 2 diabetic nephropathy patients require titration from initial dose, increase to 100 mg orally once a day. -Antihypertension is substantially present within 1 week but in some studies the maximal effect occurred in 3 to 6 weeks. Uses: -Treatment of hypertension. -To reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy. -Treatment of diabetic nephropathy with an elevated serum creatinine and proteinuria (urinary albumin to creatinine ratio 300 mg/g or greater) in patients with type 2 diabetes and a history of hypertension.

Usual Adult Dose for Hypertension:

Initial dose: 50 mg orally once a day Maximum dose: 100 mg orally once a day Comments: -If hypertensive patients with left ventricular hypertrophy or type 2 diabetic nephropathy patients require titration from initial dose, increase to 100 mg orally once a day. -Antihypertension is substantially present within 1 week but in some studies the maximal effect occurred in 3 to 6 weeks. Uses: -Treatment of hypertension. -To reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy. -Treatment of diabetic nephropathy with an elevated serum creatinine and proteinuria (urinary albumin to creatinine ratio 300 mg/g or greater) in patients with type 2 diabetes and a history of hypertension.

Usual Pediatric Dose for Hypertension:

6 Years or Older: Initial dose: 0.7 mg/kg orally once a day (up to 50 mg total) Comments: -May be given as a tablet or suspension. -Doses above 1.4 mg/kg (or 100 mg) daily have not been studied in pediatric patients.

Detailed Sartaxal dosage information

Overdose

If you overdose Sartaxal and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Sartaxal overdosage: fainting, feeling lightheaded, rapid heartbeat.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Sartaxal are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Sartaxal if you are allergic to Sartaxal components. Do not take Sartaxal if you're pregnant or you plan to have a baby, or you are a nursing mother. Sartaxal can harm your baby. Do not use Sartaxal if you are taking salt substitutes or potassium supplements, other blood pressure medicine, diuretic (water pill). It can be dangerous to use Sartaxal if you suffer from or have a history of liver disease, kidney disease, heart failure. If you want to achieve most effective results without any side effects it is better to avoid alcohol. Avoid machine driving. Do not stop taking Sartaxal suddenly.

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Aminopeptidase PC from the hepatopancreas of the Kamchatka crab Paralithodes camtshatica. alpha-Globulin, the high-molecular-weight protein fraction from Sesamum indicum L., was hydrolyzed to low-molecular-weight protein and peptides by pepsin, while its resistance to hydrolysis by group-specific enzymes, trypsin or alpha-chymotrypsin, was very high. A good adhesion to the substrate and a columnar structure were observed by the fractured cross-sectional view of the SDC films on NiO-YSZ anode substrate. This work was completed efficiently with a smaller experimental workload compared with the traditional method. Macrophages exhibit plasmic membrane biochemical modifications during cell activation. This report alerts emergency medicine physicians to include CSD encephalopathy (CSDE) in the differential diagnosis when a previously healthy child presents with status epilepticus. In spite of its prevalence and consequences, chronic pain is often misunderstood and inadequately managed by healthcare professionals.

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Is pharmacological neuroprotection dependent on reduced glutamate release?. Differential diagnostic delimitation using proton spin tomography. In 12 of these patients bromocriptine was replaced with cabergoline (group A), while the remaining ones continued treatment with bromocriptine, the dose of which was halved, and administered together with metformin (group B). Seasonal variations in activity rhythms of male voles: mediation by gonadal hormones. As compared to para-like channels, the protein products from this gene have deletions in the N-terminus and in the DII-DIII linker region. Ras-related protein Rap GTPase has been implicated in cell adhesion, cell proliferation, and cell junction formation. Selection of foxes, separately, for tame and for aggressive behavior has yielded two strains with markedly different, genetically determined, behavioral phenotypes.

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Peer-Mediated Intervention for the Development of Social Interaction Skills in High-Functioning Autism Spectrum Disorder: A Pilot Study. Heterocyclic N-Oxides - An Emerging Class of Therapeutic Agents. The Timeline Course Graphing Scale for the DSM-5 Mood Disorders (TCGS) is described and accompanied with guidelines for administration. Examination of annual age-adjusted and age-specific primary pulmonary hypertension mortality in the United States from 1979 through 1996 and in five selected states from 1992 through 1996. Because of the relatively long existence of the NRR assay, its practicality and its proven usefulness for particular purposes, ECVAM decided to review the status of the method, in order to decide whether prevalidation and formal validation studies on the test might be profitable. The work presented studied the impact of these environmental variables on post-germination carrot growth to nominal seedling emergence. The author discusses issues to be considered in choosing the language to be spoken during the interview and using a translator. The consequences are pointed out that may arise in daily administrative practice, in particular in Public Health Offices. Localization of calcium and zinc in the sperm storage tubules of chicken, quail and turkey using X-ray microanalysis.

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Body image appears to play a role in the association between ADHD and depression symptoms for college students. However, whether RCAN1 plays an important role in non-syndromic CHD is unknown. Upon insertion into the r gene, this chimeric element generated an 8-bp target-site duplication, characteristic of P elements. Immunohistochemical identification of erythroid precursors in paraffin embedded bone marrow sections: spectrin is a superior marker to glycophorin. Therefore graft copolymers were produced at oil/water interface, due to the multifunctional character of these inisurfs and constituted the particle inner core with covalent links to the dextran coverage. High index of suspicion is paramount for its early diagnoses to prevent orthopedic and cardiac complications. Expression levels of several lncRNAs are abnormally up-regulated or down-regulated and play a primary role in colorectal cancer (CRC) cell tumorigenesis. In this paper we focus on the less obvious possibilities of the clinical use of ACEI in neurological or oncological patients, discuss the role of ACE gene polymorphism and show the perspectives of potentially new applications of ACEI in contemporary pharmacotherapy. Tumor growth recurred twice and the diagnosis after the third operation was epidermoid carcinoma.

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In vivo kinematics were collected with a magnetic tracking device on eight healthy volunteers. SCN10A is a member of the voltage-gated sodium channel (VGSC) gene family. To evaluate the influence of naringin on PMMA-induced osteoclastic bone resorption using the mouse air sacs model. Procedural data including the number of dedicated aspirate passes were recorded. Susceptibility test methods found to be most reliable for detecting MRSA in the USA include the broth microdilution MIC determination (performed in salt-supplemented broth), the Bauer-Kirby test with slight modification, or oxacillin-salt agar screening plates. In this study we sequenced the complete mt genomes of the freshwater gastropods Radix swinhoei (Lymnaeidae) and Planorbarius corneus (Planorbidae). IL-37 and Smad3 were accumulated in the macrophage-derived foam cells in the plaque and significantly increased in protein and RNA levels. Our measurements indicate that motility bias likely results from the polarization of pilus activity, yielding variable levels of movement in different directions.

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Ruthenium red staining of the endolymphatic sac in the guinea pig. The DATT is an easy, inexpensive, and reliable test to assess peritoneal transport type, and it also provides information about peritoneal clearance of solutes and ultrafiltration. Comparison of Transoral/Transnasal Endoscopic-Guided Adenoidectomy with Endoscopic Nasopharyngeal Inspection at the End of Curettage Adenoidectomy. Analysis of cerebroarterial Doppler flow velocity waveforms in newborn infants: towards an index of cerebrovascular resistance. We describe here a transposon-based DNA sequencing strategy that allows the introduction of sequencing priming sites throughout a target sequence by bacterial mating. Our results indicated that the peptides were effective in inhibiting both the nuclear translocation and transcriptional activation of NF-kappaB. Knock down of tumor cell Timp-1 suppressed Met signaling in metastases and inhibited metastasis formation and tumor cell-scattering in the liver. Clinical pharmacokinetics of verapamil, nifedipine and diltiazem. Estimated annual incidence of human cases of blastomycosis in Illinois increased from 3.8 to 10.7 cases/1 million persons/y from 2001 through 2007.

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Genetic inhibition of AMPK inhibits autophagy induction in cells with defective mitochondria, while genetic inhibition of autophagy has no effect on AMPK activation. CNP-22 stimulates, rather than inhibits, water drinking in the rat: evidence for a unique biological action of the C-type natriuretic peptides. For improvement of pain and/or function in women with vestibulodynia (provoked localized vulvodynia), there was fair evidence that vestibulectomy was of benefit, but the size of the effect cannot be determined with confidence. The structure of organelles of the endocytic pathway in hydrated cryosections of cultured cells. Human nasal tissue was incubated with fluticasone propionate, budesonide, flunisolide and beclomethasone-17-monopropionate. The antibodies to neurohormonal anti-genes as a criterion of early diagnostic and neurointoxication in workers of chemical enterprises.

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