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Indoc (Indomethacin)

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Indoc is a non-steroidal anti-inflammatory drug (NSAID). It blocks proteins in your body that cause pain and swelling. Indoc is not a controlled substance. It's not known to be habit-forming.

Other names for this medication:
Artid, Artisid, Donica, Ducain, Edcin, Idicin, Indmecin, Indoc, Indocap, Indocid, Indoflam, Indol, Indomethacin, Indonet, Indopar, Indoriv, Inmecin, Inocin, Methadocin, Microcid, Recticin, Tissop

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Trandate, Pyridium, Mysoline, Flagyl, Vermox, Hydrea, Theolair, Neurontin, Arimidex, Cleocin, Acnex, Syziral, Vanasulf, Glyson, Diamode, Skelaxin, Norten, Medformin, Loctenk,

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Also known as: Indomethacin


Indomethacin injection is used to treat patent ductus arteriosus (PDA) in premature infants (babies born too early) who weigh between 500 and 1750 grams. PDA is a heart problem where a blood vessel, the ductus arteriosus, fails to close normally after birth. This blood vessel is only used before birth, and is no longer needed after the baby is born. Indomethacin injection works by causing the PDA to constrict, and this closes the blood vessel. This medicine is used when other medical treatment for PDA fails after 48 hours.

This medicine is available only with your doctor's prescription.


This section provides information on the proper use of a number of products that contain indomethacin. It may not be specific to Indoc. Please read with care.

For safe and effective use of this medicine, do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. Using too much of this medicine may increase the chance of unwanted effects.

This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.

When used for severe or continuing arthritis, this medicine must be used regularly as ordered by your doctor in order for it to help you. This medicine usually begins to work within one week, but in severe cases up to two weeks or even longer may pass before you begin to feel better. Also, several weeks may pass before you feel the full effects of this medicine.

Do not take rectal suppositories by mouth or use it in the vagina.

To use the suppository:

If the suppository is too soft to insert, chill it in the refrigerator for 30 minutes or run cold water over it before removing the foil wrapper. Remove the foil wrapper and moisten the suppository with cold water. Lie down on your side and use your finger to push the suppository well up into the rectum Remain lying down for about 15 minutes to keep the suppository from coming out before it melts. Make sure to wash your hands with soap and water before and after inserting this medicine.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For rectal dosage form (suppositories): For moderate to severe ankylosing spondylitis, osteoarthritis, or rheumatoid arthritis: Adults and children older than 14 years of age—One 50-milligram (mg) suppository, inserted into the rectum up to 3 times a day. Children up to 14 years of age—Use and dose must be determined by your doctor. For acute painful shoulder caused by bursitis or tendinitis: Adults and children older than 14 years of age—One suppository inserted into the rectum 3 to 4 times a day. Children up to 14 years of age—Use and dose must be determined by your doctor. For gout: Adults and children older than 14 years of age—One suppository inserted into the rectum 3 times a day. Children up to 14 years of age—Use and dose must be determined by your doctor.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include severe drowsiness, stomach pain, or vomiting.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Indoc dosage information

Side effects

The most common side effects associated with Indoc are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Indoc can increase your risk of fatal heart attack or stroke, even if you don't have any risk factors. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

Indoc may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using this medicine, especially in older adults.

You should not use Indoc if you are allergic to it, or if you have ever had an asthma attack or severe allergic reaction after taking aspirin or an NSAID.

Tell your doctor if you have ever had:

heart disease, high blood pressure; a heart attack, stroke, or blood clot; fluid retention; bleeding problems; stomach ulcers or bleeding; asthma; liver or kidney disease; or if you smoke.

If you are pregnant, you should not take Indoc unless your doctor tells you to. Taking an NSAID during the last 20 weeks of pregnancy can cause serious heart or kidney problems in the unborn baby and possible complications with your pregnancy.

This medicine may temporarily affect fertility (ability to have children) in women.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

Indoc is not approved for use by anyone younger than 14 years old.

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Cytotoxicity effected by a class II restricted T cell line specific for an encephalitogenic epitope. Effects of ditch-buried straw return on water percolation, nitrogen leaching and crop yields in a rice-wheat rotation system. To clarify whether reactivated cytomegalovirus (CMV) infections in critically ill patients lead to worse outcome or just identify more severely ill patients. This review summarizes current evidence on use of surveillance histology for the clinical practice of renal transplantation. We experimentally find a strong variation in the local detection efficiency of the device. One size does not fit all: the case for tailoring print materials. The effect of heating and fermenting on antioxidant properties of white cabbage. Catalytic activities of alkaline phosphatase and N-acetyl-beta-D-glucosaminidase in human cortical nephron segments: heterogeneous changes in acute renal failure and acute rejection following kidney allotransplantation. The results indicate a heterogeneous pattern of arterial alterations in which systolic BP, cigarette smoking and blood glucose level are implicated.

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